Jiang Yan-Yi, Wang Ming-Rong
State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100021, China.
Yi Chuan. 2012 May;34(5):519-25. doi: 10.3724/sp.j.1005.2012.00519.
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies with poor prognosis in China. Patients with ESCC may present with vague symptoms in early stage and most of the cases are diagnosed at advanced stage, without the chance of optimal therapy. In the development and progression of ESCC, cytogenetic and molecular aberrations are frequently observed. This review is to summarize the advances in the chromosomal and genomic alterations of ESCC reported recently.
食管鳞状细胞癌（ESCC）是中国最常见且预后较差的恶性肿瘤之一。ESCC患者在早期可能出现模糊症状，大多数病例在晚期才被诊断出来，没有机会接受最佳治疗。在ESCC的发生和发展过程中，经常观察到细胞遗传学和分子异常。本综述旨在总结近期报道的ESCC染色体和基因组改变的研究进展。
