Casada J H, Dafny N
Department of Neurobiology and Anatomy, University of Texas Health Science Center, Houston.
Int J Neurosci. 1990 Aug;53(2-4):265-74. doi: 10.3109/00207459008986614.
The present experiment investigated whether repeated exposure to an acute stressor elicits changes in sensory evoked responses recorded from awake rats. Animals were restrained for four hours per day on each of four consecutive days. Recordings were obtained on the day prior to the first restraint and following the first and fourth day of restraint. Restraint generally resulted in an increase in the amplitude of sensory evoked responses recorded from the medial basal hypothalamus (MBH), dorsal hippocampus (DH), and superior colliculus (SC) without changing any other characteristics of the recording. A persistent increase in the averaged evoked response amplitudes seen on both the first and fourth daily presentation of the stressor indicates that no significant adaptation to the stressor occurred over this time period as measured electrophysiologically.
本实验研究了反复暴露于急性应激源是否会引起清醒大鼠记录的感觉诱发电位变化。在连续四天中的每一天，动物每天被束缚四小时。在第一次束缚前一天以及第一次和第四次束缚后进行记录。束缚通常会导致从内侧基底下丘脑（MBH）、背侧海马（DH）和上丘（SC）记录的感觉诱发电位幅度增加，而记录的任何其他特征均未改变。在应激源每日首次和第四次呈现时均观察到平均诱发电位幅度持续增加，这表明在这段时间内，通过电生理学测量，对该应激源没有发生显著适应。
