Iwasaki Y, Kinoshita M, Ikeda K, Takamiya K, Shiojima T
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Int J Neurosci. 1990 Oct;54(3-4):191-5. doi: 10.3109/00207459008986635.
A study was undertaken to elucidate the existence of cognitive and memory impairments in patients with amyotrophic lateral sclerosis (ALS) by comparing a group of ALS patients with both nonneurological medical controls (MC) and healthy controls (HC) on neuropsychological tests. We also examined the relationship between the severity of motor disabilities and intellectual impairment. Twenty-two ALS patients, 18 MCs and 17 HCs participated. The tests used were the Mini-mental state examination (MMS) and the immediate and delayed memory tests. The mean MMS score of the ALS patients was lower than the mean scores of both control groups. In the memory tests, there were significant differences between the ALS group and the two control groups. Correlation analyses of several motor symptoms and neuropsychological results revealed that there was a significant negative correlation between upper motor neuron symptoms and MMS, as well as memory tests. The evidence for multisystem degeneration in ALS has prompted speculation that more sensitive neuropsychological measurements might reveal cerebral dysfunction in ALS patients who are not presenting evident dementia.
通过在神经心理学测试中将一组肌萎缩侧索硬化症（ALS）患者与非神经科医学对照（MC）组和健康对照（HC）组进行比较，开展了一项研究以阐明ALS患者是否存在认知和记忆障碍。我们还研究了运动功能障碍严重程度与智力障碍之间的关系。22例ALS患者、18例MC和17例HC参与了研究。所使用的测试为简易精神状态检查表（MMS）以及即时和延迟记忆测试。ALS患者的MMS平均得分低于两个对照组的平均得分。在记忆测试中，ALS组与两个对照组之间存在显著差异。对多种运动症状和神经心理学结果的相关性分析显示，上运动神经元症状与MMS以及记忆测试之间存在显著负相关。ALS多系统退化的证据促使人们推测，更敏感的神经心理学测量可能会揭示未表现出明显痴呆的ALS患者存在脑功能障碍。
