自然杀伤细胞、缺氧与滋养层细胞分化。
NK cells, hypoxia and trophoblast cell differentiation.
机构信息
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA.
出版信息
Cell Cycle. 2012 Jul 1;11(13):2427-30. doi: 10.4161/cc.20542.
Abstract
Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal interface, natural killer (NK) cells and invasive trophoblast cells. Hypoxia-inducible factor (HIF) transcription factors direct cellular responses to low oxygen, influencing trophoblast lineage commitment and promoting development of the invasive trophoblast lineage. This short review focuses on role of NK cells on uterine spiral artery development and subsequent modulation of oxygen tensions at the maternal fetal interface.
摘要
绒毛膜胎盘的特征是母体血管的广泛重塑，将其转化为松弛的低阻力血管。这一过程极大地促进了母亲和胎儿之间营养物质和气体的交换。在母体胎儿界面上已经确定了两种调节这些血管变化的关键调节剂，即自然杀伤 (NK) 细胞和侵袭性滋养层细胞。缺氧诱导因子 (HIF) 转录因子指导细胞对低氧的反应，影响滋养层谱系的决定，并促进侵袭性滋养层谱系的发育。这篇简短的综述重点介绍了 NK 细胞在子宫螺旋动脉发育中的作用以及随后对母体胎儿界面氧张力的调节。
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Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions.自然杀伤细胞通过调节缺氧诱导因子依赖的滋养细胞谱系决定来指导血绒毛膜胎盘形成。
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