大鼠胎盘形成：研究合胞体母体-胎儿界面的实验模型。
Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface.
机构信息
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
出版信息
Placenta. 2012 Apr;33(4):233-43. doi: 10.1016/j.placenta.2011.11.026. Epub 2012 Jan 28.
Abstract
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the hemochorial placenta. The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research.
摘要
大鼠具有血绒毛膜胎盘，其特点是深层的宫内滋养细胞浸润和滋养细胞定向的子宫螺旋动脉重塑；这些特征与人类胎盘的特征相同。对这些相似性的认识促使人们建立了使用大鼠作为动物模型的体外和体内研究方法，以解决关于血绒毛膜胎盘发育的机制问题。本文综述的目的是提供必要的背景知识，以帮助推动大鼠在胎盘研究中发挥主导作用。
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本文引用的文献
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Placenta. 2012 Jan;33(1):67-72. doi: 10.1016/j.placenta.2011.10.013. Epub 2011 Nov 12.
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Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions.自然杀伤细胞通过调节缺氧诱导因子依赖的滋养细胞谱系决定来指导血绒毛膜胎盘形成。
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Knockout rats generated by embryo microinjection of TALENs.通过胚胎显微注射转录激活样效应因子核酸酶（TALENs）产生的基因敲除大鼠。
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