Krakau T, Mullins D, Langham M
Department of Experimental Ophthalmology University of Lund, Malmoë, Sweden.
Invest Ophthalmol Vis Sci. 1990 Dec;31(12):2551-9.
The intraocular pressure-dependent light sensitivity of discrete retinal points was measured using the Heijl-Krakau automated light-emitting diode perimeter with an appropriate software program. A total of 300 measurements of light sensitivity were recorded from six retinal points during the test period of 8-10 min; increased intraocular pressure was induced using a Langham scleral suction-cup system. The ocular pulsatile blood flow and the ophthalmic arterial pressure were measured in the same patients. The fluctuation of the light sensitivity was less than 5% over the test period in healthy eyes and remained unaffected by an intraocular-pressure increment of 20 mm Hg; a small decrease of sensitivity occurred at a pressure increment of 30 mm Hg. In glaucomatous eyes the light sensitivity was lower and the fluctuation of the light sensitivity at some but not all retinal points was substantially greater than in the controls. In the glaucomatous eyes, and intraocular-pressure increment of 20 mm Hg increased the fluctuation and decreased the light sensitivity. The pulsatile ocular blood flow was lower in the glaucomatous eyes but not severe enough to be solely responsible for the loss of vision. The coexistence of retinal points with normal and abnormal stabilities of light sensitivity in glaucomatous eyes was consistent with impaired blood flow in the lamina cribrosa.
使用配有合适软件程序的海伊-克拉考自动发光二极管视野计，测量离散视网膜点的眼压依赖性光敏感度。在8至10分钟的测试期内，从六个视网膜点共记录了300次光敏感度测量值；使用兰厄姆巩膜吸盘系统升高眼压。对同一患者测量眼搏动性血流和眼动脉压。在健康眼中，测试期内光敏感度波动小于5%，眼压升高20 mmHg时仍不受影响；眼压升高30 mmHg时敏感度出现小幅下降。在青光眼眼中，光敏感度较低，部分而非全部视网膜点的光敏感度波动明显大于对照组。在青光眼眼中，眼压升高20 mmHg会增加波动并降低光敏感度。青光眼患者的搏动性眼血流较低，但严重程度不足以单独导致视力丧失。青光眼眼中光敏感度稳定性正常和异常的视网膜点并存，这与筛板血流受损一致。
