Institute of Molecular and Cell Biology, Singapore.
Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a011221. doi: 10.1101/cshperspect.a011221.
Hedgehog proteins are intercellular signaling molecules that play a central role in animal development. In response to the signal, Gli zinc finger proteins are shuttled along the primary cilium to the nucleus to activate target genes.
Hedgehog 蛋白是细胞间信号分子,在动物发育中发挥核心作用。Gli 锌指蛋白在初级纤毛中沿信号被转运到细胞核,从而激活靶基因。