Graduate Program in Health and Rehabilitation Sciences, Faculty of Health Sciences, The University of Western Ontario, London, Canada.
Disabil Rehabil. 2012;34(26):2291-9. doi: 10.3109/09638288.2012.683233. Epub 2012 Jun 5.
To summarize the potential origins of fatigue poststroke from a neuromuscular perspective, including stroke-induced alterations at the cortical, spinal and muscle levels.
Perspective based on narrative literature review.
Fatigue is a highly prevalent, but poorly understood symptom poststroke. Neuromuscular fatigue has central and peripheral origins. Individuals with stroke experienced greater central fatigue and less peripheral fatigue during voluntary contractions of the paretic leg in comparison to healthy participants. Neuromuscular adaptations to stroke create an increased susceptibility to central fatigue, which may be a contributing factor to the increased perception of tiredness during performance of activities of daily living. Future studies should investigate whether intervention-induced cortical plasticity, gains in muscle strength and endurance will attenuate self-reported fatigability.
Fatigue is a common and debilitating consequence of stroke. Neuromuscular fatigue of central origin may contribute to self-reported fatigue. Continued focused and properly designed research studies should provide substantial insight into the therapeutic interventions that will improve the management of fatigue poststroke.
从神经肌肉角度总结脑卒中后疲劳的潜在来源，包括皮质、脊髓和肌肉水平的卒中诱导改变。
基于叙事文献综述的观点。
疲劳是脑卒中后一种高度普遍但理解不足的症状。神经肌肉疲劳有中枢和外周来源。与健康参与者相比，脑卒中患者在瘫痪侧腿部进行自主收缩时经历了更大的中枢疲劳和更小的外周疲劳。对脑卒中的神经肌肉适应会增加对中枢疲劳的易感性，这可能是导致日常生活活动时疲劳感增加的一个因素。未来的研究应调查干预引起的皮质可塑性、肌肉力量和耐力的增加是否会减轻自我报告的疲劳程度。
疲劳是脑卒中的常见且使人虚弱的后果。中枢来源的神经肌肉疲劳可能导致自我报告的疲劳。持续的有针对性和设计合理的研究将为改善脑卒中后疲劳的治疗干预措施提供重要的见解。
