Torrado J J, Illum L, Cadorniga R, Davis S S
Departamento de Farmacia y Technologia Farmaceutica, Facultad de Farmacia, Universidad Complutense, Ciudad Universitaria, Madrid, Spain.
J Microencapsul. 1990 Oct-Dec;7(4):471-7. doi: 10.3109/02652049009040469.
Egg albumin microspheres containing paracetamol for oral administration were prepared and their in vivo characteristics evaluated. The egg albumin microspheres were able to improve the organoleptic characteristics of paracetamol formulations. The pharmacokinetic characteristics of three different formulations of paracetamol were evaluated in six volunteers. The formulations administered orally were: (1) Paracetamol granulated with lactose (reference), (2) Egg albumin microspheres and (3) Egg albumin microspheres coated with polymethacrylate. The pharmacokinetic characteristics for formulations 1 and 2 were similar but formulation 3 gave significant differences (p less than 0.05) in Ka, Cmax and tmax. No significant differences in relative bioavailability were observed.
制备了含对乙酰氨基酚的口服卵清蛋白微球，并对其体内特性进行了评估。卵清蛋白微球能够改善对乙酰氨基酚制剂的感官特性。在6名志愿者中评估了三种不同对乙酰氨基酚制剂的药代动力学特性。口服的制剂有：(1) 与乳糖制粒的对乙酰氨基酚（参比制剂），(2) 卵清蛋白微球，以及(3) 用聚甲基丙烯酸酯包衣的卵清蛋白微球。制剂1和2的药代动力学特性相似，但制剂3在吸收速率常数（Ka）、最大血药浓度（Cmax）和达峰时间（tmax）方面有显著差异（p小于0.05）。未观察到相对生物利用度有显著差异。
