冠心病“年轻”与“非年轻”患者血脂异常的模式及决定因素：印度北部一项多中心随机观察研究
Patterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: a multicentric, randomised observational study in northern India.
作者信息
Sinha Nakul, Kumar Sudeep, Rai Himanshu, Singh Neha, Kapoor Aditya, Tewari Satyendra, Saran R K, Narain V S, Bharadwaj R P S, Bansal R K, Saxena P C, Sinha P R, Gupta P R, Mishra Mukul, Jain Praveen, Pandey C M, Singh Uttam, Agarwal S S
机构信息
Sahara India Medical Institute, Lucknow, Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
出版信息
Indian Heart J. 2012 May-Jun;64(3):229-35. doi: 10.1016/S0019-4832(12)60078-9.
AIMS
The aims of the study were to ascertain difference in lipid levels of 'Young' onset of coronary artery disease (CAD) (≤ 45 years) vs. 'Not so Young' onset of CAD (≥ 55 years) among north Indians and also to investigate determinants of 'dyslipidaemia' in CAD patients.
METHODS
This was a prospective, multicentric, randomised, observational study carried in eight centres of UP, India. All blood investigations were performed employing a central laboratory.
RESULTS
Out of a total 435 patients studied, 218 were in the 'young group' (YG) and 235 were in the 'Not so Young Group' (NSYG). Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG.
CONCLUSION
We conclude that lipid levels among north Indians are significantly higher in younger patients with CAD when compared with elderly.
目的
本研究的目的是确定北印度人群中“年轻”（≤45岁）发病的冠状动脉疾病（CAD）患者与“非年轻”（≥55岁）发病的CAD患者的血脂水平差异，并调查CAD患者“血脂异常”的决定因素。
方法
这是一项在印度北方邦的八个中心进行的前瞻性、多中心、随机、观察性研究。所有血液检查均在中央实验室进行。
结果
在总共435名研究患者中，218名在“年轻组”（YG），235名在“非年轻组”（NSYG）。与NSYG相比，YG中血脂异常更为常见，总胆固醇、甘油三酯、低密度和极低密度脂蛋白胆固醇水平显著更高。糖尿病、高血压、城市生活方式和CAD家族史被发现是YG中血脂异常的重要决定因素。
结论
我们得出结论，与老年人相比，北印度年轻CAD患者的血脂水平显著更高。
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