Lewis Peter A, Wright Kay, Webster Anne, Steer Matthew, Rudd Michael, Doubrovsky Anna, Gardner Glenn
Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia.
J Burn Care Res. 2012 Jul-Aug;33(4):e195-200. doi: 10.1097/BCR.0b013e31825042e2.
Postburn itch is reported to affect up to 87% of the burn population. Although treatments for postburn itch are multimodal, they remain consistently ineffective. However, recent anecdotal evidence from several outpatients at a tertiary referral hospital suggests that a cream combining beeswax and several herbal oils may be effective in the minimization of postburn itch. The aim of this study was to test the efficacy of beeswax and herbal oil cream against the standard treatment of aqueous cream in the provision of relief from the symptoms of postburn itch. A randomized controlled trial compared two groups using a visual analog scale, frequency of cream application, itch recurrence after cream application, use of antipruritic medications, and sleep disturbance to determine the effect of itch severity and duration. Fifty-two participants were enrolled in the study (84% male) with a mean age of 35 years (SD = 16) and mean burn TBSA of 7.2% (SD = 7.7). Study results found that the beeswax and herbal oil cream reduce itch after application more frequently than aqueous cream (P = .001). In addition, when managed with beeswax and herbal oil cream, participants found that their itch recurred later (P ≤ .001) and their use of antipruritic medications was lower (P = .023). Findings of this study suggest beeswax and herbal oil cream to be more effective in the minimization of postburn itch than aqueous cream. Given this, a larger study examining the efficacy of beeswax and herbal oil cream appears warranted.
据报道,烧伤后瘙痒影响多达87%的烧伤患者。尽管烧伤后瘙痒的治疗方法是多模式的,但仍然一直无效。然而,一家三级转诊医院的几位门诊患者最近的轶事证据表明,一种结合了蜂蜡和几种草药油的乳膏可能有效地减轻烧伤后瘙痒。本研究的目的是测试蜂蜡和草药油乳膏相对于水性乳膏标准治疗在缓解烧伤后瘙痒症状方面的疗效。一项随机对照试验使用视觉模拟量表、乳膏涂抹频率、涂抹乳膏后瘙痒复发情况、止痒药物的使用以及睡眠障碍来比较两组,以确定瘙痒严重程度和持续时间的影响。52名参与者被纳入研究(84%为男性),平均年龄35岁(标准差=16),平均烧伤总面积为7.2%(标准差=7.7)。研究结果发现,蜂蜡和草药油乳膏涂抹后比水性乳膏更频繁地减轻瘙痒(P = .001)。此外,使用蜂蜡和草药油乳膏治疗时,参与者发现瘙痒复发较晚(P≤.001),且止痒药物的使用较少(P = .023)。本研究结果表明,蜂蜡和草药油乳膏在减轻烧伤后瘙痒方面比水性乳膏更有效。鉴于此,似乎有必要进行一项更大规模的研究来检验蜂蜡和草药油乳膏的疗效。