Grégoire N
Laboratoire de Biochimie et Circulation cérébrale, CHU Timone, Marseille.
J Radiol. 1990 Aug-Sep;71(8-9):481-7.
The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of nonfenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted. Exchanges through the BBB depend on whether the substances exchanged are soluble in water or in lipids. Hydrosoluble substances are largely excluded from the brain by the BBB; liposoluble substances pass the barrier easily by passive or active mechanisms. Water movements through the BBB are related to variations in osmolality. These data are of the utmost importance in all brain diseases with rupture of the BBB and in all neuroradiological procedures using contrast media.
血脑屏障（BBB）存在于三个部位：脑血管、脉络丛和蛛网膜。它由通过紧密连接相互连接的无窗内皮细胞或上皮细胞组成。从生化角度来看，血脑屏障由磷脂双分子层构成，其中插入了球状蛋白质。通过血脑屏障的物质交换取决于所交换的物质是水溶性还是脂溶性。水溶性物质大多被血脑屏障阻挡在脑外；脂溶性物质则通过被动或主动机制轻松穿过该屏障。水通过血脑屏障的移动与渗透压的变化有关。这些数据在所有血脑屏障破裂的脑部疾病以及所有使用造影剂的神经放射学检查中都至关重要。
