Yu Xin, He Guorong, Du Guanhua
Beijing Key laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(4):421-5.
Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease.
黄芩素是从传统中药黄芩的干燥根中提取的一种黄酮类化合物，已被广泛用作抗氧化剂和抗炎剂。随着对其作用机制的不断研究，最近的研究结果表明，黄芩素对帕金森病等神经退行性疾病具有一定的神经保护作用并能改善临床症状。最近的研究表明，其神经保护功效与抗炎、抗氧化应激、保护线粒体、抑制谷氨酸神经毒性、促进神经生长以及抑制α-突触核蛋白聚集活性等功能密切相关。本文旨在总结黄芩素在帕金森病中的神经保护作用。
