孕中期胎儿近端肾小管中的坏死上皮细胞：这是“急性肾小管坏死”吗？
Necrotic epithelial cells in proximal renal tubules of 2nd trimester fetuses: is this "acute tubular necrosis"?
作者信息
Peres Luiz Cesar, Sethuraman Chitra, Al-Adnani Mudher, Cohen Marta Cecilia
机构信息
Department of Histopathology, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, S10 2TH, United Kingdom.
出版信息
Int J Clin Exp Pathol. 2012;5(4):326-30. Epub 2012 Apr 16.
PURPOSE
The aim of this study is to describe the occurrence of necrotic tubular cells in kidneys of non-macerated fetuses.
METHODS
Description of histology and immunostaining results using C9 immunostain of proximal tubular epithelium of kidneys from 30 consecutive non-macerated fetuses' autopsies.
RESULTS
the gestational age ranged from 13 to 22 weeks. The mean gestational age was 18.6 weeks; the cause of death was acute chorioamnionitis in 13 cases (43.3%), termination of pregnancy for fetal anomalies in 13 (43.3%) and other causes in 4 (13.3%). Histology of the kidneys revealed vacuolation of proximal tubule epithelial cells (100%), dilatation of tubules (93.4%) and tubular cell necrosis (53.4%). C9 immunostaining was positive in 24 cases (80%) and was seen in all gestational ages.
CONCLUSIONS
These results indicate that tubular cell necrosis is not an uncommon finding in the kidneys of 2(nd) trimester fetuses and may represent acute tubular necrosis (ATN). C9 is a helpful marker in confirming this diagnosis. Future studies may further explore this preliminary observation.
目的
本研究旨在描述未浸软胎儿肾脏中坏死肾小管细胞的发生情况。
方法
对连续30例未浸软胎儿尸体解剖所得肾脏近端肾小管上皮进行组织学描述及使用C9免疫染色的免疫染色结果描述。
结果
孕周为13至22周。平均孕周为18.6周；死亡原因是急性绒毛膜羊膜炎13例（43.3%），因胎儿畸形终止妊娠13例（43.3%），其他原因4例（13.3%）。肾脏组织学显示近端肾小管上皮细胞空泡化（100%）、肾小管扩张（93.4%）和肾小管细胞坏死（53.4%）。C9免疫染色24例呈阳性（80%），且在所有孕周均可见。
结论
这些结果表明，肾小管细胞坏死在孕中期胎儿肾脏中并非罕见发现，可能代表急性肾小管坏死（ATN）。C9是确诊此诊断的有用标志物。未来研究可能会进一步探索这一初步观察结果。
Zotero 插件