(-)-多卡瓦醇 A 的全合成：铃木-宫浦偶联反应方法。

Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach.

机构信息

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan.

出版信息

Org Lett. 2012 Jun 15;14(12):3186-9. doi: 10.1021/ol301278e. Epub 2012 Jun 6.

Abstract

A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis , has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.

摘要

从食用海藻江蓠中分离得到的海洋致死毒素(-)-聚沙蟾毒精 A 的全合成已通过汇聚方法实现。该合成的特点是通过催化不对称合成两个关键片段，并通过铃木-宫浦偶联和 Keck 大环内酯化将它们连接起来。