Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Ann N Y Acad Sci. 2012 Jun;1257:193-8. doi: 10.1111/j.1749-6632.2012.06507.x.
Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
斑马鱼脑室形态发生涉及初始循环独立的开口，随后是血流和循环依赖性的扩张过程。斑马鱼闭合蛋白-5a 对于建立神经上皮-脑室屏障是必需的，该屏障维持脑室腔内的静水压力，从而有助于脑室开口和扩张。在哺乳动物中，包括闭合蛋白-3 和闭合蛋白-5 在内的几个闭合蛋白家族成员在血脑屏障的微血管内皮细胞中表达。斑马鱼脑室形态发生是否为研究这些闭合蛋白在早期胚胎发育中的作用提供了模型尚不清楚。本文重点介绍了这些斑马鱼闭合蛋白在脑室形态发生过程中的表达和功能。
