School of Life Science, Bharathidasan Univ, Palkalaiperur, Tiruchirappalli, Tamil Nadu, India.
J Food Sci. 2012 Jul;77(7):T119-23. doi: 10.1111/j.1750-3841.2012.02755.x. Epub 2012 Jun 1.
In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan-induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan-induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were lower in the extract-treated group and high-density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2-diphenyl-2-picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus.
The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes.
在印度的本土医学体系中，芫荽（CS），通常用作食物成分，据称对各种疾病都有疗效。为了确定其在糖尿病中的效用，本研究评估了芫荽在链脲佐菌素诱导的糖尿病大鼠中的降血糖和抗氧化作用。提取物中含有生物活性化合物，包括酚类、类黄酮、类固醇和单宁。芫荽提取物在链脲佐菌素诱导的糖尿病大鼠中显著降低血糖水平。将 CS 提取物的降血糖活性与临床可用药物格列本脲进行了比较。提取物治疗组的血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平较低，高密度脂蛋白胆固醇高于糖尿病对照组大鼠。CS 提取物对 2,2-二苯基-2-苦基肼自由基具有很强的清除作用，并抑制脂质过氧化。提取物的自由基清除作用与参考抗氧化剂相当。此外，它还表现出改善的抗氧化潜力，如降低脂质过氧化和显著增加糖尿病大鼠肝脏中各种抗氧化酶（如过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶）的活性。这些结果表明，提取物可以保护肝功能，并在糖尿病大鼠中表现出降血糖、降血脂和抗氧化作用。这些结果支持将这种植物提取物用于治疗糖尿病。
如果将这种植物芫荽的叶子和茎用于烹饪，将是治疗糖尿病的一种方法。
