Masters D K, Hopkins A D
J Trop Med Hyg. 1979 May;82(5):99-101.
A prospective comparative trial of four amoebicide regimes was carried out with protozoological control using 300 patients presenting with symptomatic intestinal amoebiasis at a tropical rural hospital during a five month period. 195 (76.2%) of 256 treated supplied three follow-up stools. Of those treated with Metronidazole and Oxytetracycline 10.9 per cent continued to excrete Entamoeba histolytica while with Di-iodohydroxyquinoline and Oxytetracycline the figure was 25.5 per cent falling to 20.0 per cent when Dehydroemetine was added and with Clioquinol and Oxytetracycline 27.5 per cent continued to excrete Entamoeba histolytica. These figures with the absolute numbers of patients involved do not show any one of the regimes used to be significantly more effective than the others in unclassified symptomatic intestinal amoebiasis. We conclude therefore that in the rural situation the cheapest regime should be preferred as the standard one, namely Clioquinol and Oxytetracycline. However, in view of the reported serious side-effects of Clioquinol, Di-iodomydroxyquinoline and Oxytetracycline could be considered as the second cheapest and with slightly better results.
在一家热带乡村医院，对300例有症状的肠道阿米巴病患者进行了为期5个月的前瞻性比较试验，采用四种杀阿米巴药物方案，并进行原虫学对照。256例接受治疗的患者中有195例（76.2%）提供了三次随访粪便样本。在接受甲硝唑和土霉素治疗的患者中，10.9%的患者继续排出溶组织内阿米巴；而在接受双碘喹啉和土霉素治疗的患者中，这一比例为25.5%，加入去氢依米丁后降至20.0%；在接受氯碘羟喹和土霉素治疗的患者中，27.5%的患者继续排出溶组织内阿米巴。这些数据以及涉及的患者绝对数量表明，在未分类的有症状肠道阿米巴病中，所使用的任何一种方案都没有明显比其他方案更有效。因此，我们得出结论，在农村地区，最便宜的方案，即氯碘羟喹和土霉素，应作为标准方案首选。然而，鉴于氯碘羟喹有严重副作用的报道，双碘喹啉和土霉素可被视为第二便宜且效果稍好的方案。
