Shigeta Takanobu, Sakamoto Seisuke, Kanazawa Hiroyuki, Fukuda Akinari, Kakiuchi Toshihiko, Karaki Chiaki, Uchida Hajime, Matsuno Naoto, Tanaka Hideaki, Kasahara Mureo
Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
Pediatr Transplant. 2012 Aug;16(5):496-500. doi: 10.1111/j.1399-3046.2012.01722.x. Epub 2012 Jun 4.
DH is a rare complication following LT. This report presents three cases of right-sided DH after LT using a left-sided graft. All of the patients were younger than one yr of age, and they were critically ill owing to their original disease, characterized by biliary atresia, progressive familiar intrahepatic cholestasis, and acute liver failure. DH occurred with sudden onset within three months after LT. All of the cases were promptly diagnosed and treated. A literature review of 24 cases of DH identified four factors associated with DH: left-sided graft, right-sided DH, relatively delayed onset of DH, and age-specific chief complaint. DH following LT should be considered as a potential surgical complication when a left-sided graft is used, especially in small infants with coagulopathy and malnutrition.
供肝移植术后肝门部胆漏(DH)是一种罕见的并发症。本报告介绍了3例采用左侧供肝行肝移植术后发生右侧DH的病例。所有患者年龄均小于1岁,因原发性疾病病情危重,其特征为胆道闭锁、进行性家族性肝内胆汁淤积症和急性肝衰竭。DH在肝移植术后3个月内突然发病。所有病例均得到及时诊断和治疗。对24例DH病例的文献回顾确定了与DH相关的四个因素:左侧供肝、右侧DH、DH相对延迟发作以及特定年龄的主要症状。当使用左侧供肝时,尤其是在患有凝血病和营养不良的小婴儿中,肝移植术后的DH应被视为一种潜在的手术并发症。