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活体肝移植供体肝切除术后的膈肌疝:一种未得到充分认识的严重并发症。

Diaphragmatic herniation following donor hepatectomy for living donor liver transplantation: a serious complication not given due recognition.

作者信息

Lochan Rajiv, Saif Rehan, Ganjoo Naveen, Sakpal Mallikarjun, Panackal Charles, Raja Kaiser, Reddy Jayanth, Asthana Sonal, Jacob Mathew

机构信息

Aster Integrated Liver Care Group, Aster CMI Hospital, Bangalore, Karnataka, India.

Aster Integrated Liver Care Group, Aster MedCity Hospital, Kochi, Kerala, India.

出版信息

Ann Hepatobiliary Pancreat Surg. 2017 Nov;21(4):232-236. doi: 10.14701/ahbps.2017.21.4.232. Epub 2017 Nov 30.

Abstract

A clear appreciation of benefits and risks associated with living donor hepatectomy is important to facilitate counselling for the donor, family, and recipient in preparation for living donor liver transplant (LDLT). We report a life-threatening complication occurring in one of our live liver donors at 12 weeks following hemi-liver donation. We experienced five donor complications among our first 50 LDLT: Clavien Grade 1, n=1; Clavien grade 2, n=3; and Clavien grade 3B, n=1. The one with Clavien grade 3B had a life-threatening diaphragmatic hernia occurring 12 weeks following hepatectomy. This was promptly recognized and emergency surgery was performed. The donor is well at 1-year follow-up. Here we provide a review of reported instances of diaphragmatic hernia following donor hepatectomy with an attempt to elucidate the pathophysiology behind such occurrence. Life-threatening donor risk needs to be balanced with recipient benefit and risk on a tripartite basis during the counselling process for LDLT. With increasing use of LDLT, we need to be aware of such life-threatening complication. Preventive measures in this regard and counselling for such complication should be incorporated into routine work-up for potential live liver donor.

摘要

清楚认识活体肝切除相关的益处和风险,对于在活体肝移植(LDLT)准备过程中为供体、家属和受体提供咨询非常重要。我们报告了一例半肝捐献后12周发生在我们一位活体肝供体身上的危及生命的并发症。在我们最初的50例LDLT中,我们经历了5例供体并发症:Clavien 1级,n = 1;Clavien 2级,n = 3;Clavien 3B级,n = 1。这位Clavien 3B级的供体在肝切除术后12周发生了危及生命的膈疝。这一情况被及时发现并进行了急诊手术。该供体在1年随访时情况良好。在此,我们回顾已报道的供体肝切除术后膈疝病例,试图阐明此类情况背后的病理生理学机制。在LDLT咨询过程中,危及生命的供体风险需要在三方基础上与受体的益处和风险相平衡。随着LDLT使用的增加,我们需要意识到这种危及生命的并发症。这方面的预防措施以及针对此类并发症的咨询应纳入潜在活体肝供体的常规检查中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcfe/5736745/ea19f18a071a/ahbps-21-232-g001.jpg

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