甲状腺的发育缺陷：与母亲高龄的关系
Developmental defects of the thyroid gland: relationship with advanced maternal age.
作者信息
Kirmızibekmez Heves, Güven Ayla, Yildiz Metin, Cebeci Ayşe Nurcan, Dursun Fatma
机构信息
Göztepe Education and Training Hospital, Department of Pediatric Endocrinology, İstanbul, Turkey.
出版信息
J Clin Res Pediatr Endocrinol. 2012 Jun;4(2):72-5. doi: 10.4274/jcrpe.560.
OBJECTIVE
Developmental defects of the thyroid gland are the most frequent causes of permanent congenital hypothyroidism. This study aimed to investigate the epidemiological features of patients with thyroid dysgenesis (TD).
METHODS
Medical records of 234 patients with TD followed between the years 2008 and 2010 were evaluated retrospectively. Diagnosis was made by ultrasonography.
RESULTS
Of 234 patients, 120 (51.3%) were male and 114 (48.7%) were female. Male to female ratio was 1.08 and there were no significant differences in epidemiologic and clinical findings between girls and boys. One hundred eighty-three patients (78.2%) were diagnosed as hypoplasia, 35 (14.9%) as thyroid agenesis, 4 as ectopic thyroid gland and 12 as hemiagenesis. The mean maternal age of the group was 28.9 ± 0.4 years (range 18 to 45 years), which is significantly higher than the recently reported mean maternal ages for Turkish women.
CONCLUSIONS
Advanced maternal age was more prevalent in patients with TD. Our clinical and epidemiologic findings suggested no evidence of sexual dimorphism.
目的
甲状腺发育缺陷是永久性先天性甲状腺功能减退最常见的病因。本研究旨在调查甲状腺发育异常（TD）患者的流行病学特征。
方法
回顾性评估2008年至2010年间随访的234例TD患者的病历。通过超声检查进行诊断。
结果
234例患者中，男性120例（51.3%），女性114例（48.7%）。男女比例为1.08，女孩和男孩在流行病学和临床发现方面无显著差异。183例患者（78.2%）被诊断为发育不全，35例（14.9%）为甲状腺缺如，4例为异位甲状腺，12例为半侧缺如。该组产妇的平均年龄为28.9±0.4岁（范围18至45岁），显著高于最近报道的土耳其女性产妇平均年龄。
结论
TD患者中高龄产妇更为普遍。我们的临床和流行病学发现未显示出性别差异的证据。
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