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MECP2 promotes the migration and invasion of gastric cancer cells by modulating the Notch1/c-Myc/mTOR signaling pathways by suppressing FBXW7 transcription.
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Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis.
Mol Cancer Ther. 2012 May;11(5):1155-65. doi: 10.1158/1535-7163.MCT-12-0066. Epub 2012 Mar 2.
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Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.
Nat Cell Biol. 2012 Mar 4;14(4):375-85. doi: 10.1038/ncb2463.
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CDC4/FBXW7 and the 'just enough' model of tumourigenesis.
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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.
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GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
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SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.
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The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia.
Leuk Res. 2012 Jan;36(1):110-6. doi: 10.1016/j.leukres.2011.09.013. Epub 2011 Oct 11.
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Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
J Cell Biochem. 2011 Dec;112(12):3882-90. doi: 10.1002/jcb.23321.
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The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
J Biol Chem. 2011 Nov 11;286(45):39282-9. doi: 10.1074/jbc.M111.253807. Epub 2011 Sep 27.
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The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.
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