亮氨酸丰富重复、免疫球蛋白样和跨膜域 3（LRIT3）是 FGFR1 的调节剂。
Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.
机构信息
Section of Genetics, Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA 95817, USA.
出版信息
FEBS Lett. 2012 May 21;586(10):1516-21. doi: 10.1016/j.febslet.2012.04.010. Epub 2012 Apr 20.
Abstract
Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-?. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.
摘要
成纤维细胞生长因子受体（FGFRs）通过多种信号通路，包括 MAPK、PI3K/AKT 和 PLC-γ，在颅面和骨骼发育中发挥关键作用。FGFR 介导的信号转导受多种调节剂的调节。富含亮氨酸重复（LRR）和/或免疫球蛋白（IG）超家族结构域的蛋白被认为与 FGFR 相互作用。此外，纤连蛋白富含亮氨酸重复跨膜蛋白 3（FLRT3）已被证明通过纤连蛋白 III 型（FNIII）结构域调节 FGFR 介导的信号转导。因此，具有 LRR、IG 和 FNIII 的蛋白是 FGFR 的候选调节剂。在这里，我们将富含亮氨酸重复、免疫球蛋白样和跨膜域 3（LRIT3）鉴定为 FGFR 的调节剂。
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