[局限性硬皮病发病机制中细胞免疫及血管生成变化作用的研究]
[Studies of the role of cellular immunity and angiogenetic changes in the pathogenesis of circumscribed scleroderma].
作者信息
Majewski S, Błaszczyk M, Chibowska M, Rosińska-Borkowska D, Kencka D, Rudnicka L, Marczak M, Makieła B, Skiendzielewska A, Jabłońska S
机构信息
Kliniki Dermatologicznej AM w Warszawie.
出版信息
Przegl Dermatol. 1990 Jul-Aug;77(4):249-51.
The studies were performed in 48 patients with morphea and included evaluation of 1) antinuclear antibodies 2) lymphocyte induced angiogenesis 3) natural killer (NK) cell activity and 4) T cell subpopulations in peripheral blood. The presence of antinuclear antibodies was found in 44.4% (8/18) patients with scleroderma linearis and in 21% (4/19) patients with morphea disseminata. Lymphocyte induced angiogenesis was increased in 41.5% (17/41) morphea patients, mainly in cases with pronounced vascular changes. The E rosette forming test showed a decreased percentage of active rosette forming cells (ARFC) and total rosette forming cells (TRFC) in peripheral blood and the NK cell activity was lowered in patients with morphea. These results obtained in patients with morphea show some similarities and differences in comparison to cellular immunity disturbances in patients with systemic scleroderma.
对48例硬斑病患者进行了研究，包括评估：1）抗核抗体；2）淋巴细胞诱导的血管生成；3）自然杀伤（NK）细胞活性；4）外周血中的T细胞亚群。在44.4%（8/18）的线状硬皮病患者和21%（4/19）的播散性硬斑病患者中发现了抗核抗体。41.5%（17/41）的硬斑病患者淋巴细胞诱导的血管生成增加，主要见于血管变化明显的病例。E玫瑰花结形成试验显示外周血中活性玫瑰花结形成细胞（ARFC）和总玫瑰花结形成细胞（TRFC）的百分比降低，硬斑病患者的NK细胞活性降低。与系统性硬皮病患者的细胞免疫紊乱相比，硬斑病患者的这些结果显示出一些异同。
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