Ahmed Zahra, Powell Robert, Llewelyn Gareth, Anstey Alex
Dermatology Department, University Hospital Wales, Cardiff, UK.
BMJ Case Rep. 2011 Dec 1;2011:bcr0820114674. doi: 10.1136/bcr.08.2011.4674.
A 53-year-old woman with chronic plaque psoriasis treated with adalimumab (antitumour necrosis factor (anti TNF) α therapy) for 10 months presented with an 8 week history of hyperesthesia in a 'glove and stocking' distribution and clumsiness on walking. Nerve conduction studies confirmed the clinical diagnosis of a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). She was admitted and treated with intravenous immunoglobulin and oral steroids and made an excellent recovery. To our knowledge, this is the first published report of CIDP associated with anti TNF α therapy given to treat psoriasis.
一名53岁患有慢性斑块状银屑病的女性，接受阿达木单抗（抗肿瘤坏死因子（抗TNF）α治疗）10个月后，出现了8周的“手套和袜套”样分布的感觉异常以及行走笨拙。神经传导研究证实了慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）的临床诊断。她入院后接受了静脉注射免疫球蛋白和口服类固醇治疗，恢复良好。据我们所知，这是第一份关于使用抗TNFα治疗银屑病相关的CIDP的发表报告。
