一名双相情感障碍患者因锂盐-氯氮平治疗继发完全性房室传导阻滞及复发性多发性硬化症。
Complete AV-block secondary to lithium-clozapine therapy and relapsing multiple sclerosis in a bipolar patient.
作者信息
Gabeler Edward E E, van Miltenburg Addy J M
机构信息
Cardiology Department, Sint Franciscus Gasthuis, Rotterdam, Netherlands.
出版信息
BMJ Case Rep. 2011 Dec 1;2011:bcr1020115030. doi: 10.1136/bcr.10.2011.5030.
A complete atrioventricular block (CAVB) can be a lethal complication when it is not treated directly with isoprenaline and pacemaker therapy. The overall incidence of CAVB varies between 4 to 8 per cent with a mortality OR of 3.2 within 30 days if untreated. Main causes of CAVB are inferior myocardial infarction, congenital AV node malformation, mitral valve insufficiency and valve surgery, metabolic disorders and intoxications. The authors describe a case with a CAVB due to lithium-clozapine therapy and relapsing multiple sclerosis.
完全性房室传导阻滞（CAVB）若不直接采用异丙肾上腺素和起搏器治疗，可能会成为一种致命并发症。CAVB的总体发病率在4%至8%之间，若未治疗，30天内的死亡率比值比为3.2。CAVB的主要病因包括下壁心肌梗死、先天性房室结畸形、二尖瓣关闭不全及瓣膜手术、代谢紊乱和中毒。作者描述了一例因锂盐-氯氮平治疗及复发性多发性硬化症导致CAVB的病例。
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