多发性硬化症中心脏复极化异常：与大鼠变应性脑脊髓炎模型的关系。

Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat.

作者信息

Drouin E, Nataf S, Lande G, Louboutin J P

机构信息

Department of Pediatrics, University Hospital, Nantes, France.

出版信息

Muscle Nerve. 1998 Jul;21(7):940-2. doi: 10.1002/(sici)1097-4598(199807)21:7<940::aid-mus13>3.0.co;2-u.

DOI:10.1002/(sici)1097-4598(199807)21:7<940::aid-mus13>3.0.co;2-u

PMID:9626255

Abstract

Ventricular repolarization was investigated for the first time in 48 multiple sclerosis (MS) patients using measurement of QTc interval on standard electrocardiographic recordings. The repolarization process was prolonged significantly in MS compared to control subjects (P = 0.0001). This result was confirmed with an animal model of MS, i.e., the experimental allergic encephalomyelitis in rat. The contribution of prolonged QT to syncopal attack or sudden cardiac death in MS patients need further investigation.

摘要

首次对48例多发性硬化症（MS）患者进行心室复极化研究，通过在标准心电图记录上测量QTc间期来进行。与对照组相比，MS患者的复极化过程明显延长（P = 0.0001）。这一结果在MS动物模型中得到证实，即大鼠实验性过敏性脑脊髓炎。QT延长对MS患者晕厥发作或心源性猝死的影响有待进一步研究。