小鼠和大鼠脊髓中的自发性原发性星形细胞瘤。

Spontaneous primary astrocytoma in the spinal cord of a mouse and a rat.

作者信息

Frith C H, Chandra M

机构信息

Toxicology Pathology Associates, Little Rock, Arkansas 72211.

出版信息

Toxicol Pathol. 1990;18(3):427-9. doi: 10.1177/019262339001800311.

DOI:10.1177/019262339001800311

PMID:2267503

Abstract

A spontaneous astrocytoma was observed as an incidental finding in the thoracic spinal cord of a control Charles Rivers CD-1 female mouse from a 2 yr oncogenicity study. An astrocytoma was also observed in the lumbar spinal cord of a Charles Rivers Sprague-Dawley control, female rat from a 2 yr oncogenicity study. The mouse was clinically normal and was sacrificed at the end of the 2 yr study. The rat was killed at 512 days of age because of posterior paralysis.

摘要

在一项为期2年的致癌性研究中，从对照的Charles Rivers CD - 1雌性小鼠的胸段脊髓中偶然发现了一个自发性星形细胞瘤。在另一项为期2年的致癌性研究中，从对照的Charles Rivers Sprague - Dawley雌性大鼠的腰段脊髓中也发现了一个星形细胞瘤。该小鼠临床正常，在2年研究结束时被处死。这只大鼠在512日龄时因后肢麻痹而被处死。