Central Salt and Marine Chemicals Research Institute (CSIR), Bhavnagar 364002, Gujarat, India.
Org Lett. 2012 Jun 15;14(12):2980-3. doi: 10.1021/ol3009733. Epub 2012 Jun 7.
A newly synthesized imine-based receptor (L) showed remarkable specificity toward the Hg(2+) ion in aqueous media over other metal ions. Coordination of L to Hg(2+) induces a turn-on fluorescence response. This was explained based on the restricted imine isomerization along with PET on coordination to Hg(2+). X-ray structural evidence tends to favor a C-C bond rotation rather than C═N isomerization for adopting a favorable conformation in L for coordination to Hg(2+). This reagent could be used for imaging the accumulation of Hg(2+) ions in HeLa cells.
一种新合成的亚胺基受体（L）在水相介质中对 Hg(2+) 离子表现出显著的选择性，优于其他金属离子。L 与 Hg(2+) 的配位诱导了荧光的开启响应。这可以根据配位到 Hg(2+)时受阻的亚胺异构化和 PET 来解释。X 射线结构证据倾向于支持 C-C 键旋转而不是 C═N 异构化，以便 L 采用有利于与 Hg(2+)配位的有利构象。该试剂可用于在 HeLa 细胞中成像 Hg(2+)离子的积累。
