Sarashina H, Taniyama S, Saitoh N, Nunomura M, Nakayama H, Okui K
Chirurgische Klinik, Universität Chiba, Japan.
Strahlenther Onkol. 1990 Dec;166(12):794-7.
We studied an effect of preoperative radiation upon the change of tumor volume in rectal carcinoma. As a preliminary study, tumor volume of 15 cases of rectal carcinoma with no preoperative irradiation was estimated preoperatively using the transrectal ultrasonography, and were compared with those determined by resected specimens after operation. As a result, there was a parallel relationship between the two values, and mean estimation error rate was 14.6%. Next, the same method was applied to 15 patients with rectal carcinoma who underwent preoperative radiation in order to detect the reduction rate of tumor volume after radiation therapy (42.6 Gy). As a consequence, 80% of cases exhibited the reduction rate more than 50% with an average of 61.7%. It was suggested that the determination of pre- and postoperative tumor volume would be beneficial to evaluation of preoperative radiation therapy as well as decision of the optimal dose of radiation in rectal carcinoma.
我们研究了术前放疗对直肠癌肿瘤体积变化的影响。作为一项初步研究，使用经直肠超声对15例未接受术前放疗的直肠癌患者的肿瘤体积进行术前评估，并与术后切除标本所确定的肿瘤体积进行比较。结果，这两个值之间存在平行关系，平均估计误差率为14.6%。接下来，将相同方法应用于15例接受术前放疗的直肠癌患者，以检测放疗（42.6 Gy）后肿瘤体积的缩小率。结果，80%的病例缩小率超过50%，平均为61.7%。提示术前和术后肿瘤体积的测定有助于评估直肠癌术前放疗以及确定最佳放疗剂量。
