Department of General Psychology, University of Padua, Padua, Italy.
Biol Psychol. 2012 Sep;91(1):22-7. doi: 10.1016/j.biopsycho.2012.05.009. Epub 2012 Jun 4.
This study examined cardiovascular activity and autonomic involvement during sleep in essential hypotension. We compared young female hypotensives and normotensives using ambulatory blood pressure monitoring, impedance cardiography, and frequency-domain analysis of heart rate variability during a night of polysomnographic recording. Hypotensives, as compared to normotensives, exhibited lower blood pressure, reduced myocardial contractility and reduced sympathovagal balance across the whole night. Both groups exhibited a reduction in cardiovascular involvement from wake to sleep with similar cardiovascular activity during wake and REM. No group difference was observed in sleep architecture suggesting similar sleeping quality in hypotensives and normotensives. The lower blood pressure and reduced myocardial contractility associated with a lower sympathovagal balance in hypotensives, as compared to normotensives, suggest a night-time hypoactivation of the cardiovascular system supporting the hypothesis of impairment in autonomic control in essential hypotension.
本研究旨在探讨原发性低血压患者睡眠期间的心血管活动和自主神经参与情况。我们通过动态血压监测、阻抗心动描记法和心率变异性的频域分析，比较了年轻女性原发性低血压患者和血压正常者在一整晚多导睡眠记录期间的情况。与血压正常者相比，低血压者的血压较低，心肌收缩力降低，整个夜间的交感神经-副交感神经平衡也受到影响。两组患者在清醒和 REM 期间的清醒状态下和 REM 期间的心血管活动相似，都呈现出从清醒到睡眠时心血管参与度降低的情况。在睡眠结构方面，两组之间没有差异，这表明低血压患者和血压正常者的睡眠质量相似。与血压正常者相比，原发性低血压患者的血压较低，心肌收缩力降低，交感神经-副交感神经平衡较低，这表明夜间心血管系统的活动减弱，支持原发性低血压患者自主神经控制受损的假说。
