轮状病毒免疫应答及其保护相关因素。
Rotavirus immune responses and correlates of protection.
机构信息
Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia.
出版信息
Curr Opin Virol. 2012 Aug;2(4):419-25. doi: 10.1016/j.coviro.2012.05.003. Epub 2012 Jun 5.
Abstract
Selected topics in the field of rotavirus immunity are reviewed focusing on recent developments that may improve efficacy and safety of current and future vaccines. Rotaviruses (RVs) have developed multiple mechanisms to evade interferon (IFN)-mediated innate immunity. Compared to more developed regions of the world, protection induced by natural infection and vaccination is reduced in developing countries where, among other factors, high viral challenge loads are common and where infants are infected at an early age. Studies in developing countries indicate that rotavirus-specific serum IgA levels are not an optimal correlate of protection following vaccination, and better correlates need to be identified. Protection against rotavirus following vaccination is substantially heterotypic; nonetheless, a role for homotypic immunity in selection of circulating postvaccination strains needs further study.
摘要
本文主要关注轮状病毒免疫领域的最新研究进展，探讨这些进展可能对现有和未来疫苗的有效性和安全性产生的影响。轮状病毒（RV）已发展出多种机制来逃避干扰素（IFN）介导的固有免疫。与世界上更发达的地区相比，在发展中国家，自然感染和疫苗接种所诱导的保护作用降低，这些国家存在多种因素，包括高病毒挑战负荷和婴儿在早期感染。发展中国家的研究表明，轮状病毒特异性血清 IgA 水平不是疫苗接种后保护作用的最佳预测指标，需要进一步确定更好的预测指标。疫苗接种后的轮状病毒保护作用具有显著的异型性；然而，同型免疫在选择循环后疫苗接种株中的作用仍需要进一步研究。
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