Franco Manuel A, Angel Juana, Greenberg Harry B
Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia.
Vaccine. 2006 Apr 5;24(15):2718-31. doi: 10.1016/j.vaccine.2005.12.048. Epub 2006 Jan 17.
Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans.
轮状病毒是全球范围内儿童严重脱水腹泻的最常见病因。轮状病毒肠胃炎在全球的发病率极高，尤其是在发展中国家，这凸显了使用疫苗预防相关发病和死亡的必要性。然而，人们对轮状病毒免疫的了解并不完全。目前，感染后不久检测的血清总RV IgA似乎是预防轮状病毒的最佳保护标志物。本综述描述了目前对轮状病毒免疫的理解，包括从选定动物模型中获得的预防轮状病毒的机制，以及与人类自然感染或疫苗接种相关的保护关联。
