Lacko A, Kreze A, Pechán J, Putz Z, Fodor G, Velemínský J
Endokrinologický ústav, Lubochna.
Vnitr Lek. 1990 Nov;36(11):1113-8.
The work is focused on the possibility of early diagnosis of diabetic microangiopathy. The authors used examination of microcirculation by the method of tissue clearance of Na 131I. In a group of 106 patients with diabetes thus the microcirculation of the lower extremities in the subcutaneous layer and the calf muscle was examined. A group of 36 healthy subjects served as control. An altered microcirculation was found in 75% type 1 diabetics and in all type 2 diabetics. In those with an altered microcirculation only in 23% type 1 diabetics and in 17% type 2 diabetics organ manifestations of diabetic microangiopathy (i.e. retinopathy and nephropathy) were lacking. It seems thus that altered Na 131I absorption in the lower extremities is an earlier sign of microangiopathic affection than identifiable organ changes. Examination of tissue clearance of Na 131I thus could reveal in time individuals threatened by this complication of diabetes.
这项工作聚焦于糖尿病微血管病变早期诊断的可能性。作者采用¹³¹I - 钠组织清除法检测微循环。在一组106例糖尿病患者中，检测了下肢皮下层和小腿肌肉的微循环。36名健康受试者作为对照组。发现75%的1型糖尿病患者和所有2型糖尿病患者存在微循环改变。在微循环改变的患者中，仅23%的1型糖尿病患者和17%的2型糖尿病患者没有糖尿病微血管病变的器官表现（即视网膜病变和肾病）。因此，似乎下肢¹³¹I - 钠吸收改变是微血管病变的一个比可识别的器官变化更早的迹象。¹³¹I - 钠组织清除检测能够及时发现受糖尿病这一并发症威胁的个体。
