Department of Chemistry, Northeastern University, Shenyang 110819, China.
Anal Biochem. 2012 Sep 1;428(1):4-6. doi: 10.1016/j.ab.2012.05.025. Epub 2012 Jun 4.
A novel nanocomposite synthesis method of amino-modified NaYF(4):Yb,Er upconversion luminescent nanoparticles and single-walled carbon nanohorns was developed via covalent linkage for the first time. The nanocomposite was covalently coupled with rabbit anti-CEA8 antibody and then used successfully as a cell labeling agent for the immunolabeling and imaging of HeLa cells.
首次通过共价键连接的方式，开发了一种新型的氨基修饰的 NaYF(4):Yb,Er 上转换发光纳米粒子和单壁碳纳米角的纳米复合材料合成方法。该纳米复合材料与兔抗 CEA8 抗体通过共价键偶联，然后成功地用作 HeLa 细胞免疫标记和成像的细胞标记剂。
