Kon'kova-Reĭdman A B, Ratnikova L I
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2):40-5.
Patients with different forms of infections transmitted by Ixodidae ticks: meningeal and focal forms of tick-borne encephalitis, neuroborreliosis and mixed-infection (tick-borne encephalitis + Ixodidae tick borreliosis) were examined. CD-typing of lymphocytes in the cerebral spinal fluid (CSF), measuring blood and CSF cytokine content as well as blood nitric oxide (NO) metabolites were used to identify main pathogenetic mechanisms of the immune inflammation development in the central nervous system in tick-borne encephalitis associated with the hyperproduction of NO metabolites in the blood and CSF, inflammatory cytokine reaction and apoptosis. The antioxidant cytoflavin is suggested as a drug for pathogenetic treatment of neuroinfections with modifying effect of NO. The significantly rapid reduction (p<0.05) of general brain, focal brain and neuropsychological disorders as well as the decrease (p<0.05) in the endogenous hyperproduction of NO metabolites were found in patients (n=35) who received cytoflavin compared to those (n=35) who did not receive this drug. The authors recommend to use the drug in dose 10.0 ml once a day intravenously in drops during 7 − 10 days.
对患有由硬蜱传播的不同形式感染的患者进行了检查，这些感染包括蜱传脑炎的脑膜型和局灶型、神经莱姆病以及混合感染（蜱传脑炎 + 硬蜱莱姆病）。通过对脑脊液（CSF）中的淋巴细胞进行CD分型、测量血液和脑脊液中的细胞因子含量以及血液中的一氧化氮（NO）代谢产物，来确定蜱传脑炎中枢神经系统免疫炎症发展的主要发病机制，该机制与血液和脑脊液中NO代谢产物的过度产生、炎性细胞因子反应和细胞凋亡有关。抗氧化剂细胞黄素被建议作为一种对NO具有调节作用的神经感染病因治疗药物。与未接受该药物的患者（n = 35）相比，接受细胞黄素治疗的患者（n = 35）的全脑、局灶性脑和神经心理障碍显著快速减轻（p<0.05），并且内源性NO代谢产物的过度产生也有所减少（p<0.05）。作者建议以每天10.0 ml的剂量静脉滴注该药，持续7 - 10天。
