Antipenko E A
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(3 Pt 1):44-9.
The data on the effect of the succinate-containing antioxidant mexidol on the adaptation abilities of patients with chronic brain ischemia are presented. We studied 98 patients with discirculatory encephalopathy of I, II and III stages. A set of indices for psychoemotional status, functional state of the brain, autonomic status, nonspecific stability to hypoxia, adaptive reactions of the blood system and status of antioxidant defense have been used to evaluate adaptive abilities of the body. It has been shown that the introduction of the antioxidant in the treatment set strengthens the effects of basic treatment by increasing adaptive reserves of the body in stages I and II of disease that is related with the realization of reactions of urgent adaptation. The introduction of mexidol in the treatment set increases the frequency of favorable outcomes after one year of follow-up.
本文介绍了含琥珀酸的抗氧化剂美西律对慢性脑缺血患者适应能力影响的数据。我们研究了98例I、II和III期循环障碍性脑病患者。采用了一组心理情绪状态、脑功能状态、自主神经状态、对缺氧的非特异性稳定性、血液系统的适应性反应和抗氧化防御状态的指标来评估身体的适应能力。结果表明，在治疗组中引入抗氧化剂可通过增加疾病I期和II期身体的适应储备来增强基础治疗的效果，这与紧急适应反应的实现有关。在治疗组中引入美西律可提高随访一年后良好结局的发生率。
