腿长、坐高与绝经后乳腺癌风险。
Leg length, sitting height and postmenopausal breast cancer risk.
机构信息
Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
出版信息
Br J Cancer. 2012 Jun 26;107(1):165-8. doi: 10.1038/bjc.2012.244. Epub 2012 Jun 7.
BACKGROUND
Tallness has consistently been associated with an increased risk of breast cancer. We investigated the association further by decomposing height into leg length and sitting height.
METHODS
From the prospective Danish cohort 'Diet, Cancer and Health', 23 864 postmenopausal women enrolled during 1993-1997 were followed for a diagnosis of breast cancer in the Danish Cancer Registry through 2009.
RESULTS
The incidence rate ratios for breast cancer were 1.11 (95% CI=1.06-1.16) for each 5 cm increase in total height and 1.09 (95% CI=1.01-1.17) and 1.14 (95% CI=1.04-1.25) for each 5 cm increase in leg length and sitting height, respectively. There was no statistical significant difference between the associations for leg length and sitting height (P=0.47).
CONCLUSION
Leg length does not seem to be more strongly associated with breast cancer among postmenopausal women than sitting height.
背景
身高一直与乳腺癌风险增加相关。我们通过将身高分解为腿长和坐高，进一步研究了这种关联。
方法
从前瞻性丹麦队列“饮食、癌症与健康”中，1993 年至 1997 年期间招募了 23864 名绝经后妇女，通过丹麦癌症登记处随访至 2009 年，以诊断乳腺癌。
结果
总身高每增加 5 厘米，乳腺癌的发病率比为 1.11（95%CI=1.06-1.16），腿长和坐高每增加 5 厘米，发病率比分别为 1.09（95%CI=1.01-1.17）和 1.14（95%CI=1.04-1.25）。腿长和坐高之间的关联无统计学显著差异（P=0.47）。
结论
在绝经后妇女中，腿长与乳腺癌的关联似乎并不比坐高更强。
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