Tosato Filippo, Marano Salvatore, Mattacchione Stefano, Luongo Barbara, Mingarelli Valentina, Campagna Giuseppe
Referral Center for Surgical Treatment of Gastroesophageal Reflux Diseases, Department of Surgery F. Durante, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Surg Laparosc Endosc Percutan Tech. 2012 Jun;22(3):205-9. doi: 10.1097/SLE.0b013e318247d3e5.
We investigated Quality of Life (QoL) and Johnsson & DeMeester score of patients after Nissen-Rossetti fundoplication.
From January 2007 to June 2008, 43 patients with chronic gastroesophageal reflux underwent laparoscopic Nissen-Rossetti fundoplication; 7 were lost during the follow-up. Patients underwent endoscopy, 24-hour pH-metry, Gastroesophageal Reflux Disease-Health-Related Quality-of-Life (GERD-HRQL), and Short Form 36 (SF-36) questionnaires preoperatively, 6 months, and 12 months after surgery.
Endoscopic findings revealed complete healing of esophagitis in all patients. Barrett esophagus was still present. Six patients reported persistence of symptoms but postoperative pH-metry and endoscopy showed the absence of reflux; 2 patients (5.5%) were still on proton pump inhibitor therapy at 12 months. Seven patients (19.4%) reported dysphagia for solids for at least 3 months. Readmission for dysphagia was required for 2 (5.5%) and 1 patient underwent endoscopic dilatation. At 6 and 12 months, no dysphagia was reported. During the follow-up, no gas-bloat syndrome was reported. The Johnsson & DeMeester score and QoL measurement obtained from GERD-HRQL and SF-36 revealed a significant improvement in the related domain. At 6 months, 23 patients (63.8%) were completely satisfied and after 12 months, 30 patients (83.3%) were satisfied.
Nissen-Rossetti fundoplication is safe and effective for the treatment of GERD, improving QoL.
我们研究了尼森-罗塞蒂胃底折叠术后患者的生活质量（QoL）以及约翰森和德梅斯特评分。
2007年1月至2008年6月，43例慢性胃食管反流患者接受了腹腔镜尼森-罗塞蒂胃底折叠术；7例在随访期间失访。患者在术前、术后6个月和12个月接受了内镜检查、24小时pH监测、胃食管反流病健康相关生活质量（GERD-HRQL）问卷和简短健康调查问卷（SF-36）。
内镜检查结果显示所有患者食管炎均完全愈合。巴雷特食管仍然存在。6例患者报告症状持续存在，但术后pH监测和内镜检查显示无反流；2例患者（5.5%）在12个月时仍在接受质子泵抑制剂治疗。7例患者（19.4%）报告固体食物吞咽困难至少3个月。2例患者（5.5%）因吞咽困难再次入院，1例患者接受了内镜扩张治疗。在6个月和12个月时，未报告吞咽困难。在随访期间，未报告气体膨胀综合征。从GERD-HRQL和SF-36获得的约翰森和德梅斯特评分以及生活质量测量显示相关领域有显著改善。在6个月时，23例患者（63.8%）完全满意，12个月后，30例患者（83.3%）满意。
尼森-罗塞蒂胃底折叠术治疗胃食管反流病安全有效，可改善生活质量。
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