遗传性多囊肾病大鼠的肾性高血压
Renal hypertension in rats with hereditary polycystic kidney disease.
作者信息
Kaspareit-Rittinghausen J, Deerberg F, Rapp K G, Wcislo A
机构信息
Central Institute for Laboratory Animal Breeding, Hannover, F.R.G.
出版信息
Z Versuchstierkd. 1990;33(5):201-4.
PMID:2267865
Abstract
Hereditary polycystic kidney disease (PKD) was observed in a Han:SPRD rat mutant. Cysts were of tubular origin and occurrence was more pronounced in males than in females. In male rats polycystic kidney disease was associated with a marked elevation of systolic blood pressure. Therefore this rat mutant can be considered as a laboratory animal model for renal hypertension associated with adult polycystic kidney disease in man.
摘要
在一种Han:SPRD大鼠突变体中观察到遗传性多囊肾病（PKD）。囊肿起源于肾小管，在雄性大鼠中的发生率比雌性大鼠更明显。在雄性大鼠中，多囊肾病与收缩压显著升高有关。因此，这种大鼠突变体可被视为人类成人多囊肾病相关肾性高血压的实验动物模型。
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