Russell W J, Meyer-Witting M
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, South Australia.
Anaesth Intensive Care. 1990 Nov;18(4):550-2. doi: 10.1177/0310057X9001800425.
Atracurium has an unusual intrinsic Hofmann elimination which is increased by an alkaline environment and increased temperature. Normally the relaxant is stored at pH 3.3 and kept at a temperature of 4 degrees C. However, it is convenient to have a reasonable quantity available within the operating theatre. This study examined the rate of degradation of atracurium in the operating theatre environment of 20 degrees C. Atracurium within one month of its expiry date was placed in the drawer for anaesthetic drugs in each of three operating theatres. At the end of each month, further drug was added to the stock. At the end of the study, atracurium which had been stored continuously at 4 degrees C, was at 102.9% of nominal strength, having started with 113.5% at manufacture. Atracurium which had been at room temperature for one, two and three months respectively retained 99%, 95% and 92% strength respectively. These results show that even three months' exposure to room temperature does not cause enough deterioration to be clinically significant.
阿曲库铵具有特殊的内在霍夫曼消除反应，在碱性环境和温度升高时会加速。通常，该肌松药储存在pH值为3.3的环境中，并保持在4摄氏度的温度下。然而，在手术室中备有适量的药物会更方便。本研究检测了阿曲库铵在20摄氏度手术室环境中的降解速率。将有效期内一个月的阿曲库铵分别放置在三个手术室的麻醉药品抽屉中。每个月月底，向库存中添加更多药物。研究结束时，一直储存在4摄氏度的阿曲库铵，初始强度为生产时的113.5%，此时为标称强度的102.9%。分别在室温下放置了一、二、三个月的阿曲库铵，强度分别保留了99%、95%和92%。这些结果表明，即使暴露在室温下三个月，也不会导致足以产生临床显著影响的降解。
