Dermatology Department, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK.
Clin Exp Dermatol. 2013 Jan;38(1):47-9. doi: 10.1111/j.1365-2230.2012.04399.x. Epub 2012 Jun 11.
An increased frequency of renal carcinoma in men with melanoma has been reported in population based-studies. We report the clinicopathological findings of five cases of synchronous renal cell carcinoma (RCC), identified after routine radiological staging for cutaneous malignant melanoma (MM) between October 2006 and October 2008. The five patients (three men and two women, with a mean age of 62.4 years), presented with six melanomas of varying subtypes. The mean Breslow thickness was 1.87 mm. There was no family history of cancer in any of the cases. Routine radiological staging identified a mass arising from the left kidney in three cases and the right kidney in two cases. All patients underwent radical nephrectomy, and histology in each case confirmed RCC of the clear-cell subtype. Mean follow-up was 3 years. Although the simultaneous occurrence of RCC and MM may be coincidental, there are several plausible aetiological links. Further analysis of the synchronous occurrence of MM and renal cancer may provide therapeutic insights into these two important tumours.
人群研究报告显示，男性黑色素瘤患者的肾癌发病率增高。我们报告了 5 例同期发生的肾细胞癌（RCC）的临床病理发现，这些病例是在 2006 年 10 月至 2008 年 10 月期间因皮肤恶性黑色素瘤（MM）进行常规影像学分期时发现的。这 5 名患者（3 名男性和 2 名女性，平均年龄 62.4 岁）表现为 6 种不同亚型的黑色素瘤。Breslow 厚度平均值为 1.87mm。这些病例均无癌症家族史。常规影像学分期在 3 例中发现左肾有肿块，在 2 例中发现右肾有肿块。所有患者均接受了根治性肾切除术，组织学检查均证实为透明细胞型 RCC。平均随访时间为 3 年。尽管 RCC 和 MM 的同时发生可能是偶然的，但有几个合理的病因学联系。对 MM 和肾癌同时发生的进一步分析可能为这两种重要肿瘤的治疗提供新的见解。
