Division of Nephrology, Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, Hunan, PR China.
Ren Fail. 2012;34(7):934-6. doi: 10.3109/0886022X.2012.690924. Epub 2012 Jun 8.
Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease usually having a good prognosis. But the recurrence of uveitis and the chronic progression of kidney injury are still main problems. We report a 15-year-old girl with TINU who showed proteinuria, pathological renal change, multiple organ dysfunction, and immune disorders. After 2 months of 1 mg/kg/day corticosteroid therapy, 24-h urine protein, liver function tests, and creatine kinase returned to normal level. In spite of this, steroid was tapered off slowly and small dose of steroid maintenance therapy lasted for 1 year. Her kidney and ocular symptoms did not recur during 5 years of follow-up. We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome.
急性肾小管间质性肾炎和葡萄膜炎（TINU）综合征是一种罕见疾病，通常预后良好。但葡萄膜炎的复发和肾脏损伤的慢性进展仍然是主要问题。我们报告了一例 15 岁的 TINU 患者，其表现为蛋白尿、肾脏病理改变、多器官功能障碍和免疫紊乱。在接受 1mg/kg/天的皮质类固醇治疗 2 个月后，24 小时尿蛋白、肝功能检查和肌酸激酶恢复正常水平。尽管如此，皮质类固醇仍缓慢减量，并进行了 1 年的小剂量皮质类固醇维持治疗。在 5 年的随访中，她的肾脏和眼部症状没有复发。我们建议进行低剂量皮质类固醇维持治疗，以降低 TINU 综合征的复发率。
