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急性ST段抬高型心肌梗死的溶栓治疗:一项比较由全科医生主导的农村小型卫生急诊科与由内科医生主导的次区域急诊科治疗结果的试点研究。

Thrombolysis for acute ST elevation myocardial infarction: a pilot study comparing results from GP led small rural health emergency departments with results from a physician led sub-regional emergency department.

作者信息

Krones Robert, Radford Peter, Cunningham Chris, Krones David, Haines Helen M

机构信息

Rural Health Academic Centre, The University of Melbourne, Wangaratta, Victoria, Australia.

出版信息

Rural Remote Health. 2012;12:2013. Epub 2012 Jun 8.

Abstract

INTRODUCTION

Urgent angiogram is best treatment for patients presenting with ST elevation myocardial infarction (STEMI) in the first 90 min after contacting medical help. For Australian residents of inner and outer regional areas and remote or very remote areas, quick access to angiograms is not available. Numerous approaches have been developed to maximize reperfusion but delays due to systematic and patient factors persist. Diminishing confidence of some GPs in small rural health services to administer thrombolytics was one barrier to timely reperfusion identified in northeast Victoria, Australia. The aim of this study was to compare the frequency and outcomes of STEMI patients treated with thrombolysis by GPs in small rural emergency departments (EDs) with the outcomes from thrombolysis for STEMI in the physician-led, sub-regional ED in northeast Victoria.

METHODS

Data were gathered by a medical file audit. Outcome measures were the frequency of STEMI, symptom to presentation times, mode of transport to hospital, ambulance call to presentation at ED times, door to needle (DTN) times, subsequent percutanous intervention (PCI) or coronary artery bypass grafts (CABG), physician follow up and death.

RESULTS

In total 68 cases were audited. Univariate analysis showed no significant differences between the GP-led or physician-led EDs in time from onset of symptoms to presentation, DTN times, thrombolysis related complications or subsequent access to PCI or CABG. Follow-up care was similar in both groups. Transport to hospital differed between the groups with only half of all cases arriving at the ED by ambulance, almost all of which went to the sub-regional hospital.

CONCLUSIONS

Thrombolysis for STEMI in the small GP-led EDs had similar results to thrombolysis administered by the physician-led ED. There is substantial time benefit to be gained by encouraging GP-led EDs to provide thrombolysis treatment, thereby improving patient prognosis and survival.

摘要

引言

对于在联系医疗救助后的最初90分钟内出现ST段抬高型心肌梗死(STEMI)的患者,紧急血管造影是最佳治疗方法。对于澳大利亚内陆和外区域以及偏远或非常偏远地区的居民而言,无法快速进行血管造影。已经开发了多种方法来最大化再灌注,但由于系统和患者因素导致的延误仍然存在。澳大利亚维多利亚州东北部发现,一些小型农村医疗服务机构的全科医生对使用溶栓药物的信心下降是及时再灌注的一个障碍。本研究的目的是比较小型农村急诊科(ED)中由全科医生进行溶栓治疗的STEMI患者的频率和结局,与维多利亚州东北部由医生主导的次区域急诊科中STEMI溶栓治疗的结局。

方法

通过医疗文件审核收集数据。结局指标包括STEMI的频率、症状出现至就诊时间、前往医院的交通方式、救护车呼叫至在急诊科就诊时间、门至针(DTN)时间、随后的经皮介入治疗(PCI)或冠状动脉旁路移植术(CABG)、医生随访和死亡情况。

结果

共审核了68例病例。单因素分析显示,在症状出现至就诊时间、DTN时间、溶栓相关并发症或随后进行PCI或CABG方面,全科医生主导的急诊科和医生主导的急诊科之间无显著差异。两组的后续护理相似。两组前往医院的交通方式不同,所有病例中只有一半通过救护车到达急诊科,其中几乎所有都前往了次区域医院。

结论

在小型全科医生主导的急诊科中对STEMI进行溶栓治疗的结果与医生主导的急诊科进行溶栓治疗的结果相似。鼓励全科医生主导的急诊科提供溶栓治疗可带来显著的时间效益,从而改善患者的预后和生存率。

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