膜联蛋白 II 的表达上调是胃癌患者的预后标志物。
Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer.
机构信息
Department of Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, China.
出版信息
World J Surg Oncol. 2012 Jun 8;10:103. doi: 10.1186/1477-7819-10-103.
BACKGROUND
The role of annexin II in the development and progression of gastric cancer was explored.
METHODS
Real-time PCR was conducted to detect annexin II and S100A6 mRNA expression. Protein expressions of annexin II and S100A6 were also examined by immunohistochemistry in 436 clinicopathologically characterized gastric cancer cases.
RESULTS
The expression of annexin II and S100A6 mRNA differ significantly among gastric tumor tissue and matched non-cancerous gastric mucosa. Protein levels of annexin II and S100A6 were up-regulated in gastric cancer compared with adjacent non-cancerous tissues. High expression of annexin II correlated with age, location of tumor, size of tumor, differentiation, histological type, depth of invasion, vessel invasion, lymph node metastasis, distant metastasis and Tumor, Node, Metastasis (TNM) stage, and also with expression of S100A6. Further multivariate analysis suggested that expression of annexin II and S100A6 were independent prognostic indicators for gastric cancer. Cumulative five-year survival rates of patients with high expression of both annexin II and S100A6 was significantly lower than those with low expression of both.
CONCLUSION
Expression of annexin II in gastric cancer was significantly associated with depth of invasion, lymph node metastasis and distant metastasis, TNM stage, high S100A6 expression, and poor prognosis. Annexin II and S100A6 proteins could be useful prognostic marker to predict tumor progression and prognosis in gastric cancer.
背景
探讨膜联蛋白 II 在胃癌发生和发展中的作用。
方法
采用实时 PCR 检测 Annexin II 和 S100A6 mRNA 的表达。采用免疫组织化学方法检测 436 例临床病理特征明确的胃癌病例中 Annexin II 和 S100A6 的蛋白表达。
结果
胃癌组织与配对的非癌性胃黏膜组织中 Annexin II 和 S100A6 mRNA 的表达差异有统计学意义。与邻近非癌组织相比，胃癌组织中 Annexin II 和 S100A6 蛋白水平上调。 Annexin II 的高表达与年龄、肿瘤部位、肿瘤大小、分化程度、组织学类型、浸润深度、血管侵犯、淋巴结转移、远处转移、肿瘤淋巴结转移（TNM）分期以及 S100A6 的表达有关。多因素分析表明， Annexin II 和 S100A6 的表达是胃癌的独立预后指标。高表达 Annexin II 和 S100A6 的患者累积五年生存率明显低于低表达 Annexin II 和 S100A6 的患者。
结论
胃癌中 Annexin II 的表达与浸润深度、淋巴结转移和远处转移、TNM 分期、高 S100A6 表达及预后不良显著相关。 Annexin II 和 S100A6 蛋白可作为预测胃癌肿瘤进展和预后的有用预后标志物。
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