Angaut P, Cicirata F
I.N.S.E.R.M. U 106, Hôpital de la Salpêtrière, Paris, France.
Arch Ital Biol. 1990 Jul;128(2-4):315-30.
The dentato-thalamocortical projections have been studied in albino rats using anatomical and physiological approaches. The anatomical analysis reveals that the dentatothalamic input to the ventral thalamus and the thalamocortical projection from this region onto the motor cortical area have a complex topographical arrangement. The corticothalamic reverberating pathways, both direct and through a relay in the nucleus reticularis thalami, are also roughly arranged in register with the same topographical pattern. This arrangement has been reconciled with that of the motor cortex, as determined by the motor effects of intracortical microstimulations. From this is inferred a somatotopical arrangement of the cerebellar nucleus lateralis, or dentate. These observations are confirmed by the results of our physiological analysis. The movements obtained with direct microstimulations of the nucleus lateralis affect either one joint (simple movements) or, more seldom, several joints (complex movements) of the same limb. A rough rostrocaudal arrangement is found in the nucleus lateralis: the caudocentral regions of the nucleus contain the representation of the musculature of forelimb and head, whereas the hindlimb is represented in the rostralmost part of the nucleus. A more complex organization is found to be related to the three cytoarchitectonic subdivisions of the nucleus lateralis. The main, large-celled part of the nucleus is engaged in the control of the large skeletal musculature. The dorsolateral hump is involved in mouth and peri-oral activities. The ventral, parvocellular, subnucleus is involved in fine exploratory movements of vibrissae, eyes, and forelimb wrist and fingers. The implication of the dentato-thalamocortical pathways in the cortical motor activities in the rat is discussed with attention to the dentate control of the "voluntary" motricity in primates.
已采用解剖学和生理学方法对白化大鼠的齿状核 - 丘脑 - 皮质投射进行了研究。解剖学分析表明，齿状核到腹侧丘脑的输入以及该区域到运动皮质区的丘脑 - 皮质投射具有复杂的拓扑排列。皮质 - 丘脑的反馈通路，无论是直接的还是通过丘脑网状核中继的，也大致与相同的拓扑模式对齐排列。这种排列方式已与运动皮质的排列方式相协调，这是通过皮质内微刺激的运动效应确定的。由此推断出小脑外侧核或齿状核的躯体定位排列。我们的生理学分析结果证实了这些观察结果。直接微刺激外侧核所获得的运动影响同一肢体的一个关节（简单运动），或者更少见地影响几个关节（复杂运动）。在外侧核中发现了大致的 rostrocaudal 排列：核的尾中央区域包含前肢和头部肌肉组织的表征，而后肢则在核的最前端部分有所表征。发现一种更复杂的组织与外侧核的三个细胞构筑亚区有关。核的主要大细胞部分参与对大型骨骼肌的控制。背外侧隆起参与口部和口周活动。腹侧小细胞亚核参与触须、眼睛以及前肢腕部和手指的精细探索运动。本文讨论了齿状核 - 丘脑 - 皮质通路在大鼠皮质运动活动中的作用，并关注了齿状核对灵长类动物“随意”运动能力的控制。
