Department of Dermatology, Dr. Jose E. Gonzalez University Hospital, Universidad Autonoma de Nuevo Leon, Ave Madero y Ave Gonzalitos s/n, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico.
Clin Dermatol. 2012 Jul-Aug;30(4):382-8. doi: 10.1016/j.clindermatol.2011.09.008.
Subcutaneous mycoses include diverse clinical syndromes, characterized by invasion of the skin and subcutaneous tissue by saprobic fungi. Individuals living in rural areas constantly suffer lesions or trauma; however, only a few of them develop disease. In this contribution, we describe recent advances in the understanding of the virulence of these organisms, focusing on the most prevalent infections, sporotrichosis, chromoblastomycosis, and mycetoma. Although these infectious diseases are considered neglected tropical diseases, modern molecular techniques have been able to identify the etiologic agents and observe variations in the former monolithic concept of the species, which was based mostly on morphologic characteristics. The complete genetic characterization of the causative agents, along with that of their host, will help in the understanding of the factors on which the development of these infections depends.
皮下真菌病包括多种临床综合征，其特征是腐生性真菌侵袭皮肤和皮下组织。生活在农村地区的人经常遭受损伤或创伤；然而，只有少数人会患病。在本研究中，我们描述了对这些生物体毒力的最新认识进展，重点关注最常见的感染，如孢子丝菌病、着色芽生菌病和真菌性足菌肿。尽管这些传染病被认为是被忽视的热带病，但现代分子技术已经能够鉴定病原体，并观察到以前基于形态特征的单一物种概念的变化。对病原体及其宿主的完整遗传特征的研究将有助于了解这些感染发展所依赖的因素。
