The Beatson Institute for Cancer Research, Glasgow, UK.
Cell. 2012 Jun 8;149(6):1183-5. doi: 10.1016/j.cell.2012.05.024.
p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.
p53 是一种关键的肿瘤抑制蛋白，具有多种功能。其主要作用模式通常归因于压力下细胞周期停滞、细胞凋亡或衰老的诱导。Li 等人用证据挑战了这一教条，表明这三种程序对于 p53 的肿瘤抑制作用都是可有可无的。
