使 RNA 和蛋白质同步。
Getting RNA and protein in phase.
机构信息
Princeton University, Department of Chemical and Biological Engineering, NJ 08544, USA.
出版信息
Cell. 2012 Jun 8;149(6):1188-91. doi: 10.1016/j.cell.2012.05.022.
PMID:22682242
Abstract
Nonmembrane-bound organelles such as RNA granules behave like dynamic droplets, but the molecular details of their assembly are poorly understood. Several recent papers identify structural features that drive granule assembly, shedding light on how phase transitions functionally organize the cell and may lead to pathological protein aggregation.
摘要
无膜细胞器，如 RNA 颗粒，表现得像动态液滴，但它们的组装的分子细节还知之甚少。最近有几篇论文确定了驱动颗粒组装的结构特征，这些特征阐明了相转变如何在功能上组织细胞，并且可能导致病理性蛋白质聚集。
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