Delft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, Department of Bionanoscience, 2628 CJ Delft, The Netherlands.
Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318.
The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.
分子生物学的中心法则——DNA 转录为 RNA 再翻译为蛋白质——是一个信息流，在真核生物中会遇到一个物理屏障：核膜，它包裹、组织和保护基因组。核孔复合物嵌入核膜中，调节分子进出细胞核的过程，包括从细胞核输出 RNA 这一尚未被充分了解的过程。最近专注于单个分子的成像方法为信息流的这一关键步骤提供了意想不到的深入了解。本文综述了 RNA 输出的最新研究，并提出了一些关于这个复杂过程如何运作的模型。
